A prison convoy stops on the Callahan Bridge because the Colombian Cartel wants somebody else on it, and the man who will spend the rest of the game silently working his way up three criminal organisations walks out of the wreckage with a demolition expert he has never met. Claude says nothing here and says nothing later; 8-Ball does the talking for both of them, which is the arrangement for the first act.
As an opening it asks for one drive and teaches the two things the game runs on: a safehouse is where you save and where you keep a car, and Luigi's club is where the work is. Nothing in it is dangerous. Everything after it is.