Carl Johnson flies home to Los Santos for his mother's funeral and does not get out of the airport before Frank Tenpenny, Eddie Pulaski and Jimmy Hernandez pick him up. The three officers put him in the back of their car, tie him to a killing he had nothing to do with, and drop him alone in Jefferson in the middle of Ballas territory.
What is left of the mission is a bicycle and a long ride south to Grove Street. It is the game's introduction to riding and to the map, and it is also the debt the rest of the story runs on: Carl arrives home owing C.R.A.S.H. a favour he never agreed to.